The International Journal of Molecular Sciences is devoted to studies of SGLT2is in human physiology and disease. Original investigations, particularly those with solid basic\/molecular research foundations, are especially encouraged. Short communications and review articles are also welcome. Pure clinical investigations are not appropriate for submission. Please refer to the journal's Author Guidelines for more information. To submit an article, please follow the guidelines below:<\/p>\n\n\n\n
SGLT2 inhibitors cause significant BP reductions, with systolic BP lowered by 1.66 to 6.9mmHg and diastolic BP reduced by 0.88 to 3.5mmHg. In addition, SGLT2 inhibitors have no hyponatremia. Initial BP reduction is attributed to diuretic and volume-depletion effects, but longer-term effects are mediated by inhibition of the renin-angiotensin system. Hence, they are a good option for patients with type 2 diabetes.<\/p>\n\n\n\n
A common side effect of SGLT2 inhibitors is increased risk of myalgia. Nevertheless, these complications are rare and the drug can be used for short periods. Pharmacological trials are ongoing to determine long-term safety of these inhibitors. They may cause adverse side effects such as hypoglycemia and DKA, but they can also prevent kidney failure. These side effects may require pharmacovigilance.<\/p>\n\n\n\n
Inhibitors of SGLT2 function via a novel mechanism in the kidneys that inhibit renal tubular glucose reabsorption. These inhibitors decrease blood glucose without stimulating insulin secretion or b-cell function. This makes SGLT2 inhibitors an appealing option for people with diabetes who cannot tolerate insulin or have acceptable risk factors. There is also evidence of positive cardiovascular effects of SGLT2 inhibitors. Further studies are needed to establish long-term efficacy.<\/p>\n","protected":false},"excerpt":{"rendered":"
If you’ve been reading about SGLT2, you’ve probably been wondering about its role in the body. This article will explain the function of SGLT2 and its potential side effects. In addition, you’ll learn what drugs inhibit SGLT2 transport. You can also learn about the pharmacology of these drugs. But before you begin your treatment, be […]<\/p>\n","protected":false},"author":2,"featured_media":1686,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[48],"tags":[133,131,134,132],"_links":{"self":[{"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/posts\/1684"}],"collection":[{"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/comments?post=1684"}],"version-history":[{"count":1,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/posts\/1684\/revisions"}],"predecessor-version":[{"id":1689,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/posts\/1684\/revisions\/1689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/media\/1686"}],"wp:attachment":[{"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/media?parent=1684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/categories?post=1684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/survivingdiabetes.com\/wp-json\/wp\/v2\/tags?post=1684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}